Oltipraz.gif (396 Byte)

Oltipraz molecule

 

Introduction:
Oltipraz
Is a dithiole derivate (4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione, CAS: 64224-21-1) and a potent antihelmintic drug. It is effective against Schistosoma mansoni and Schistosoma hematobium. Around 100-200 million people are still suffering from Billharziosis. Despite Oltipraz is tested since 1963 (like Praziquantel, also a potent antischistosomal agent - tested since 1970) there is no solution to this problem.

Oltipraz structure
Oltipraz
ChemIDPlus

 

Why is Oltipraz interesting now ?
Later Oltipraz was detected (like many other sulfur-containing drugs) as a chemoprotective agent against toxicants - increasing the level of glutathione-S-transferases (GST).

Oltipraz is also a anticarcinogen (stomach, skin, bladder, breast, colon, pancreas, lung, liver) and proposed antimutagen. (Review)

In 1995, Oltipraz has been evaluated in residents of Qidong, People’s Republic of China, who are at high risk for exposure to aflatoxin and development of hepatocellular carcinoma. Medline [1-4]

It is also proposed as a new potential drug for the treatment of Alzheimer┤s disease and other neurodegenerative disorders (due to its ability to rise glutathione-S-transferase levels). (Nature)

 

 

Interesting patents
There are a lot of patents regarding Oltipraz, please go to Delphion.
The latest world patent of Oltipraz:

Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement - WO109118A2 with a patented synthesis of Oltipraz.(Edenland Holdings, Baybush, Ireland now Hollis-Eden)

The original US patent from Rh˘ne-Poulenc (Aventis):
1,2-Dithiole derivatives - US4110450 which is based on a french patent from 1963.

 

News
Oltipraz shows an antiangiogenic activity in certain experiments. Angiogenesis (the formation of new blood vessels) - important for the survival of cancer cells - may be blocked with Oltipraz.
Please read further abstracts at Medline or fulltext PDF.

 

Oltipraz People:

University of Missouri, Columbia - Gates Research Group LINK

Fox Chase Cancer Center: Margie L. Clapper LINK

University of Utah - Department of Pharmacology and Toxicology LINK

Information:

PLEASE send information about new research efforts of Oltipraz  to  nac@acetylcysteine.org .

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